Searchable abstracts of presentations at key conferences in endocrinology
ea0081rc13.1 | Rapid Communications 13: Adrenal and Cardiovascular Endocrinology 2 | ECE2022
HPA axis modulation by a potent inhibitor indicates 11β-hydroxysteroid dehydrogenase type 1 (HSD-1) is a main source of cortisol that can bind intracellular receptors
Background: HSD-1 converts cortisone to cortisol in tissues in which cortisol excess is associated with morbidity including liver, adipose, bone, and brain. SPI-62 is a potent HSD-1 inhibitor in clinical development for treatment of Cushings syndrome and autonomous cortisol secretion, and as adjunctive therapy to prednisolone in polymyalgia rheumatica. In Phase 1 clinical trials SPI-62 was generally well tolerated and associated with maximal liver and brain HSD-1 inhibit...
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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